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Biswajit Samanta and Dr. Claudia Höbartner Combinatorial Nucleoside-Deletion-Scanning Mutagenesis of Functional DNA Angewandte Chemie International Edition 52

Version of Record online: 1 FEB 2013 | DOI: 10.1002/anie.201208103

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Compact and informative: Individual nucleosides are statistically mutated by replacement with a non-nucleosidic spacer unit Δ that encodes the “deletion” in a single DNA library. This efficient mutagenesis approach enables minimization of functional DNA, identifying essential nucleotides, as demonstrated for two nucleic-acid ligating deoxyribozymes.

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