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M. Sc. Daniela Paunescu, Dr. Roland Fuhrer and Dr. Robert N. Grass Protection and Deprotection of DNA—High-Temperature Stability of Nucleic Acid Barcodes for Polymer Labeling Angewandte Chemie International Edition 52

Article first published online: 6 MAR 2013 | DOI: 10.1002/anie.201208135

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Tough to remove this label! When protected within a silica sphere, DNA can withstand high temperatures (up to 200 °C) and aggressive radical conditions. Following deprotection with HF, the DNA can be analyzed by standard biochemical methods. This DNA protection/deprotection scheme is compatible with standard polymer processing and can be used for labeling material of nonbiological origin.

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