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Dr. Dung T. Dang, Dr. Hoang D. Nguyen, Dr. Maarten Merkx and Prof. Dr. Luc Brunsveld Supramolecular Control of Enzyme Activity through Cucurbit[8]uril-Mediated Dimerization Angewandte Chemie International Edition 52

Article first published online: 25 JAN 2013 | DOI: 10.1002/anie.201208239

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At the double: Cucurbit[8]uril-mediated protein dimerization enables reversible control over strong enzyme activation of caspases. Simple addition of a short N-terminal FGG motif allows for a supramolecular-mediated 50-fold enhancement of caspase-9 catalytic activity.

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