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Fangrui Zhong, Xiaowei Dou, Xiaoyu Han, Weijun Yao, Qiang Zhu, Prof. Dr. Yuezhong Meng and Prof. Dr. Yixin Lu Chiral Phosphine Catalyzed Asymmetric Michael Addition of Oxindoles Angewandte Chemie International Edition 52

Article first published online: 7 DEC 2012 | DOI: 10.1002/anie.201208285

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Bifunctional phosphines derived from amino acids mediate the asymmetric Michael addition of 3-substituted oxindoles to activated alkenes (see scheme). Biologically relevant chiral 3,3-disubstituted oxindoles were thus prepared in high yields and with excellent enantioselectivities from 3-aryl- and 3-alkyl-substituted oxindoles and various activated alkenes.

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