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Dr. Hee-Sun Han, John D. Martin, Jungmin Lee, Daniel K. Harris, Prof. Dr. Dai Fukumura, Prof. Dr. Rakesh K. Jain and Prof. Dr. Moungi Bawendi Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior In Vivo Angewandte Chemie International Edition 52

Version of Record online: 17 DEC 2012 | DOI: 10.1002/anie.201208331

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Detailed arrangements: A new set of zwitterionic quantum dots were synthesized and used to study the influence of microscopic charge arrangements on the in vivo behavior of nanoparticles. Experiments using cultured cells and live mice demonstrate that the microscopic arrangement of surface charges strongly influences nonspecific binding, clearance behavior, and in vivo transport of nanoparticles.

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