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Dr. Ingrid Span, Dr. Ke Wang, Dr. Weixue Wang, Prof. Dr. Johann Jauch, Priv.-Doz. Dr. Wolfgang Eisenreich, Prof. Dr. Adelbert Bacher, Prof. Dr. Eric Oldfield and Prof. Dr. Michael Groll Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH Angewandte Chemie International Edition 52

Article first published online: 10 JAN 2013 | DOI: 10.1002/anie.201208469

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The iron–sulfur protein IspH catalyzes a key step in isoprenoid biosynthesis in bacteria and malaria parasites. Crystal structures of IspH complexed with three substrate analogues reveal their mode of binding and suggest new routes to inhibitor design.

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