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Dr. Anna L. Vagstad, Adam G. Newman, Philip A. Storm, Katherine Belecki, Prof. Jason M. Crawford and Prof. Craig A. Townsend Combinatorial Domain Swaps Provide Insights into the Rules of Fungal Polyketide Synthase Programming and the Rational Synthesis of Non-Native Aromatic Products Angewandte Chemie International Edition 52

Version of Record online: 2 JAN 2013 | DOI: 10.1002/anie.201208550

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Playing by the rules: Combinatorial domain swaps among “deconstructed” non-reducing polyketide synthases (NR-PKSs) revealed the rules behind product assembly (see scheme). The control exerted by individual catalytic domains was found to be sufficiently great that heterocombinations of domains from different NR-PKSs synthesized products in a predictable manner.

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