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Zhibo Liu, Dr. Ying Li, Jerome Lozada, Dr. Paul Schaffer, Dr. Michael J. Adam, Dr. Thomas J. Ruth and Dr. David M. Perrin Stoichiometric Leverage: Rapid 18F-Aryltrifluoroborate Radiosynthesis at High Specific Activity for Click Conjugation Angewandte Chemie International Edition 52

Version of Record online: 11 JAN 2013 | DOI: 10.1002/anie.201208551

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Raising the 18F3-BAr: Specific activities of most 18F-labeled radiotracers fall below 2 Ci μmol−1, yet 18F-aryltrifluoroborate synthesis affords specific activities as high as 15 Ci μmol−1. This has been confirmed by using click chemistry to link an [18F]-ArBF3 to rhodamine and thereby demonstrating a rapid and generalizable one-pot method for preparing a fluorescent tracer with about 10-fold higher specific activity than usual.

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