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Dr. Anthony J. Kim, Dr. Nicholas J. Boylan, Dr. Jung Soo Suk, Minyoung Hwangbo, Tao Yu, Benjamin S. Schuster, Dr. Liudimila Cebotaru, Dr. Wojciech G. Lesniak, Joon Seok Oh, Pichet Adstamongkonkul, Ashley Y. Choi, Prof. Dr. Rangaramanujam M. Kannan and Prof. Dr. Justin Hanes Use of Single-Site-Functionalized PEG Dendrons To Prepare Gene Vectors that Penetrate Human Mucus Barriers Angewandte Chemie International Edition 52

Version of Record online: 4 MAR 2013 | DOI: 10.1002/anie.201208556

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Mucus-penetrating DNA nanoparticles: A novel synthetic strategy was used to achieve a dense PEG coating on the surface of cationic polymer-based DNA nanoparticles. The dense PEG coating (blue in scheme) endows the nanoparticles with a muco-inert surface, which enables their rapid mucus penetration (trajectory indicated by gray line) and provides efficient gene transfer in various cell types.

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