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Fady Nahra, Dr. Yohan Macé, Dr. Dominique Lambin and Prof. Olivier Riant Copper/Palladium-Catalyzed 1,4 Reduction and Asymmetric Allylic Alkylation of α,β-Unsaturated Ketones: Enantioselective Dual Catalysis Angewandte Chemie International Edition 52

Article first published online: 4 FEB 2013 | DOI: 10.1002/anie.201208612

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Cooperative efforts: The catalytic coupling of the two organometallic intermediates is possible through a Cu/Pd-based dual catalysis (see scheme; LG=leaving group), in which the CuI catalytic cycle generates catalytically the starting material for the Pd0 catalytic cycle. Although reagents are present in stoichiometric amounts in the reaction mixture and are able to trap both active species, the desired reaction proceeds as planned.

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