Dr. Yaping Shang, Xiaoming Jie, Jun Zhou, Peng Hu, Shijun Huang and Prof. Dr. Weiping Su Pd-Catalyzed C–H Olefination of (Hetero)Arenes by Using Saturated Ketones as an Olefin Source Angewandte Chemie International Edition 52
Tolerant: By using Pd(OAc)2/PCy3 as a catalyst, both electron-rich aromatic heterocycles and electron-deficient fluorobenzenes undergo the dehydrogenative cross-coupling with (hetero)aryl ethyl ketones in good yields. A broad range of functional groups is tolerated, thus providing a general method for the facile syntheses of chalcones or heterocyclic chalcone analogues. Furthermore, dialkyl ketones can also participate in this transformation.
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