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Dr. Yaping Shang, Xiaoming Jie, Jun Zhou, Peng Hu, Shijun Huang and Prof. Dr. Weiping Su Pd-Catalyzed C–H Olefination of (Hetero)Arenes by Using Saturated Ketones as an Olefin Source Angewandte Chemie International Edition 52

Version of Record online: 7 DEC 2012 | DOI: 10.1002/anie.201208627

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Tolerant: By using Pd(OAc)2/PCy3 as a catalyst, both electron-rich aromatic heterocycles and electron-deficient fluorobenzenes undergo the dehydrogenative cross-coupling with (hetero)aryl ethyl ketones in good yields. A broad range of functional groups is tolerated, thus providing a general method for the facile syntheses of chalcones or heterocyclic chalcone analogues. Furthermore, dialkyl ketones can also participate in this transformation.

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