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Prof. Dr. Ismail Ibrahem, Dr. Guangning Ma, Samson Afewerki and Prof. Dr. Armando Córdova Palladium/Chiral Amine Co-catalyzed Enantioselective β-Arylation of α,β-Unsaturated Aldehydes Angewandte Chemie International Edition 52

Version of Record online: 23 NOV 2012 | DOI: 10.1002/anie.201208634

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Palladium and a simple chiral amine are used as co-catalysts for the enantioselective conjugate addition of aryl boronic acids to α,β-unsaturated aldehydes (see scheme). The synthetic utility of this co-catalyzed reaction was demonstrated in the short total syntheses of (R)-(−)-curcumene and 4-aryl-2-ones.

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