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Dr. Kui Cheng, Dr. Xiaohui Wang, Shuting Zhang and Prof. Dr. Hang Yin Inside Back Cover: Discovery of Small-Molecule Inhibitors of the TLR1/TLR2 Complex (Angew. Chem. Int. Ed. 49/2012) Angewandte Chemie International Edition 51

Article first published online: 14 NOV 2012 | DOI: 10.1002/anie.201208674

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Toll-like receptors (TLRs) play pivotal roles in innate immunity. Two key members of the TLR protein family, TLR1 (orange) and TLR2 (magenta), form a heterodimeric complex that recognizes pathogen-associated molecule patterns such as Pam3CSK4 (green) and activates inflammation response. On page 12246 ff., H. Yin and co-workers describe the new inhibitor CU-CPT22 (white), which displaces bound Pam3CSK4 from the TLR1–TLR2 complex, thus providing a valuable probe for these important signaling receptors.

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