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Dr. Dong Long and Prof. Dr. Rafael Brüschweiler Directional Selection Precedes Conformational Selection in Ubiquitin–UIM Binding Angewandte Chemie International Edition 52

Version of Record online: 20 FEB 2013 | DOI: 10.1002/anie.201208683

Thumbnail image of graphical abstract

Meeting your match: The early molecular recognition event of ubiquitin with the ubiquitin-interacting motif (UIM) of Hrs protein starts out with a directional bias in the position of UIM, increasingly favoring directions facing the binding interface of ubiquitin as the distance decreases (see figure). This process, which is driven by electrostatic long-range interactions, precedes an internal conformational population shift.

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