Dr. Slava Ziegler, Dr. Verena Pries, Dr. Christian Hedberg and Prof. Dr. Herbert Waldmann Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack Angewandte Chemie International Edition 52
How to solve the riddle? When phenotypic screens are performed, mostly there are missing pieces (of information) that would explain the link between a biologically active compound and the appearance of a certain phenotype. The interplay of organic synthesis, cell biology, proteomics, genetics, molecular biology, biochemistry, informatics, and biophysics is required to find the missing pieces and to assemble the whole puzzle of a compound's cellular activity.
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