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Erica A. Tiong, Daniel Rivalti, Benjamin M. Williams and Prof. James L. Gleason A Concise Total Synthesis of (R)-Puraquinonic Acid Angewandte Chemie International Edition 52

Version of Record online: 18 FEB 2013 | DOI: 10.1002/anie.201208792

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Distant relative: The configuration of the quaternary stereocenter in puraquinonic acid (see scheme, right) is defined by groups far removed from the point of asymmetry. The use of a bicyclic thioglycolate lactam to set the quaternary stereocenter at an early stage cuts the length of the synthesis of the natural product by nearly two thirds.

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