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Gene W. Wong and Prof. Clark R. Landis Iterative Asymmetric Hydroformylation/Wittig Olefination Sequence Angewandte Chemie International Edition 52

Article first published online: 2 JAN 2013 | DOI: 10.1002/anie.201208819

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Over and over again: Various alkenes underwent the title reaction in the presence of rhodium/bis(diazaphospholane) complexes to give γ-chiral α,β-unsaturated carbonyl products (46–96 % yield) with high enantioselectivity (90–99 % ee). Iterative sequences of the reaction lead to stereoselective C[BOND]C bond formations between achiral reactants to produce products having multiple stereocenters (see scheme, acac=acetylacetonate).

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