E-mail a Wiley Online Library Link

Prof. Dr. Takayoshi Arai, Yushi Yamamoto, Atsuko Awata, Kentaro Kamiya, Prof. Dr. Masami Ishibashi and Prof. Dr. Midori A. Arai Catalytic Asymmetric Synthesis of Mixed 3,3′-Bisindoles and Their Evaluation as Wnt Signaling Inhibitors Angewandte Chemie International Edition 52

Version of Record online: 25 JAN 2013 | DOI: 10.1002/anie.201208918

Thumbnail image of graphical abstract

TOP class: The first efficient catalytic asymmetric coupling reaction of indoles with isatin-derived nitroalkenes was accomplished by using a complex consisting of a chiral imidazoline aminophenol ligand (1; see scheme) and Cu(OTf)2. Biological activity of the newly formed chiral 3,3′-bisindoles was also confirmed in a Wnt signaling inhibitory assay.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field