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Dr. Rylan J. Lundgren, Dr. Ashraf Wilsily, Dr. Nicolas Marion, Dr. Cong Ma, Dr. Ying Kit Chung and Prof. Gregory C. Fu Catalytic Asymmetric C[BOND]N Bond Formation: Phosphine-Catalyzed Intra- and Intermolecular γ-Addition of Nitrogen Nucleophiles to Allenoates and Alkynoates Angewandte Chemie International Edition 52

Version of Record online: 21 JAN 2013 | DOI: 10.1002/anie.201208957

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Pin the amine on the gamma: A new method has been developed for the γ-addition of nitrogen nucleophiles to γ-substituted alkynoates or allenoates through intra- and intermolecular processes that are catalyzed by spirophosphine 1 (see scheme). An asymmetric version of this reaction affords enantioenriched pyrrolidines, indolines, and γ-amino-α,β-unsaturated carbonyl compounds.

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