Jiannan Zhao, Prof. Dr. Xiaohua Liu, Weiwei Luo, Mingsheng Xie, Dr. Lili Lin and Prof. Dr. Xiaoming Feng Asymmetric Synthesis of β-Amino Nitriles through a ScIII-Catalyzed Three-Component Mannich Reaction of Silyl Ketene Imines Angewandte Chemie International Edition 52
A range of β-amino nitriles containing contiguous tertiary and quaternary stereogenic carbon centers were synthesized by using the title reaction. The reaction was catalyzed by a chiral N,N′-dioxide scandium(III) complex under mild reaction conditions. Based on experimental investigations, a possible transition state has been proposed to explain the origin of asymmetric inductivity.
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