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Jiannan Zhao, Prof. Dr. Xiaohua Liu, Weiwei Luo, Mingsheng Xie, Dr. Lili Lin and Prof. Dr. Xiaoming Feng Asymmetric Synthesis of β-Amino Nitriles through a ScIII-Catalyzed Three-Component Mannich Reaction of Silyl Ketene Imines Angewandte Chemie International Edition 52

Version of Record online: 13 FEB 2013 | DOI: 10.1002/anie.201209093

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A range of β-amino nitriles containing contiguous tertiary and quaternary stereogenic carbon centers were synthesized by using the title reaction. The reaction was catalyzed by a chiral N,N′-dioxide scandium(III) complex under mild reaction conditions. Based on experimental investigations, a possible transition state has been proposed to explain the origin of asymmetric inductivity.

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