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Yuanyuan Liu and Prof. Wanbin Zhang Iridium-Catalyzed Asymmetric Hydrogenation of α-Alkylidene Succinimides Angewandte Chemie International Edition 52

Version of Record online: 18 JAN 2013 | DOI: 10.1002/anie.201209126

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Not to be out PhOXed! The title reaction provides a new approach to chiral succinimide derivatives with excellent yields and ee values by using a low catalyst loading (0.05 mol %) and mild reaction conditions. Chiral 3-benzyl pyrrolidines and 1-hydroxypyrrolidine-2,5-diones, important structural motifs in natural products and pharmaceuticals, could be readily prepared. BARF=tetrakis[3,5-bis(trifluoromethyl)phenyl]borate.

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