M. Sc. Silke Gandor, Dr. Stephanie Reisewitz, M. Tech. Muthukumaran Venkatachalapathy, Dr. Giuseppe Arrabito, Martina Reibner, Dr. Hendrik Schröder, M. Sc. Katharina Ruf, Prof. Christof M. Niemeyer, Prof. Philippe I. H. Bastiaens and Dr. Leif Dehmelt A Protein-Interaction Array Inside a Living Cell Angewandte Chemie International Edition 52
Version of Record online: 4 MAR 2013 | DOI: 10.1002/anie.201209127
Taking the bait: Protein-interaction arrays were generated in living cells by the interaction of bait-presenting artificial receptor constructs (bait-PARCs) with micrometer-scaled antibody surface patterns (see figure). This method was applied to simultaneously monitor the interaction kinetics of a prey protein with two distinct bait proteins in individual living cells.
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