Prof. Dr. Yuko Yoshikawa, Dr. Naoki Umezawa, Yuki Imamura, Prof. Dr. Toshio Kanbe, Dr. Nobuki Kato, Prof. Dr. Kenichi Yoshikawa, Prof. Dr. Tadayuki Imanaka and Prof. Dr. Tsunehiko Higuchi Effective Chiral Discrimination of Tetravalent Polyamines on the Compaction of Single DNA Molecules Angewandte Chemie International Edition 52
Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of typical, larger toroidal structures.
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