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Hongje Jang, Soo-Ryoon Ryoo, Young-Kwan Kim, Soojin Yoon, Henna Kim, Prof. Dr. Sang Woo Han, Prof. Dr. Byong-Seok Choi, Prof. Dr. Dong-Eun Kim and Prof. Dr. Dal-Hee Min Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High-Throughput Helicase Activity Assay Based on Graphene Oxide Angewandte Chemie International Edition 52

Version of Record online: 25 JAN 2013 | DOI: 10.1002/anie.201209222

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A GO-to solution: A simple graphene oxide (GO)-based assay to screen for selective inhibitors of a hepatitis C virus (HCV) helicase along with inhibitors of a severe acute respiratory syndrome coronavirus (SARS CoV) helicase was tested (see scheme). A single screen found five inhibitors highly selective for the HCV helicase orthologous to the SARS CoV helicase. Some of these hits were validated using the same GO-based assay.

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