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Patrick S. Fier and Prof. John F. Hartwig Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate Angewandte Chemie International Edition 52

Version of Record online: 10 JAN 2013 | DOI: 10.1002/anie.201209250

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The difluoromethylation of phenols with a simple, non-ozone-depleting reagent is described. The reaction occurs within minutes at room temperature with exceptional functional-group tolerance, which makes possible tandem processes for the conversion of arylboronic acids, aryl halides, and arenes to difluoromethyl ethers.

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