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Dr. Valeria Catanzaro, Dr. Concetta V. Gringeri, Dr. Valeria Menchise, Dr. Sergio Padovan, Dr. Cinzia Boffa, Dr. Walter Dastrù, Dr. Linda Chaabane, Dr. Giuseppe Digilio and Prof. Silvio Aime A R2p/R1p Ratiometric Procedure to Assess Matrix Metalloproteinase-2 Activity by Magnetic Resonance Imaging Angewandte Chemie International Edition 52

Article first published online: 28 FEB 2013 | DOI: 10.1002/anie.201209286

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Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R2p/R1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.

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