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Dr. Lei Chen, Kausar Begam Riaz Ahmed, Prof. Dr. Peng Huang and Prof. Dr. Zhendong Jin Design, Synthesis, and Biological Evaluation of Truncated Superstolide A Angewandte Chemie International Edition 52

Article first published online: 13 FEB 2013 | DOI: 10.1002/anie.201209300

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By design: A truncated superstolide A, a simplified analogue of the potent anticancer marine macrolide superstolide A, was designed and successfully synthesized by a highly efficient and convergent approach. The biological evaluation showed that this compound maintains the potent anticancer activity of the original natural product superstolide A.

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