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Dr. Tetsuhiro Nemoto, Zengduo Zhao, Takuya Yokosaka, Yuta Suzuki, Riliga Wu and Prof. Dr. Yasumasa Hamada Palladium-Catalyzed Intramolecular ipso-Friedel–Crafts Alkylation of Phenols and Indoles: Rearomatization-Assisted Oxidative Addition Angewandte Chemie International Edition 52

Version of Record online: 15 JAN 2013 | DOI: 10.1002/anie.201209317

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Inspiroation: A novel synthesis of spirocycles based on a palladium-catalyzed intramolecular ipso-Friedel–Crafts alkylation of phenols (see scheme; dba=dibenzylideneacetone) and indoles is described. Mechanistic studies show that the reaction proceeds through an unprecedented rearomatization-assisted oxidative addition.

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