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Prof. Dr. Yujiro Hayashi and Shigenobu Umemiya Pot Economy in the Synthesis of Prostaglandin A1 and E1 Methyl Esters Angewandte Chemie International Edition 52

Version of Record online: 13 FEB 2013 | DOI: 10.1002/anie.201209380

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Pot luck: Prostaglandins regulate a broad range of physiological processes and some of their derivatives are used as effective drugs, but previously their preparation has required many steps. The title compounds were efficiently synthesized in a small number of synthetic steps by using a recently developed organocatalyst and practical, one-pot operations involving several successive reactions.

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