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Dr. Nicolas D. Werbeck, Dr. John Kirkpatrick and Dr. D. Flemming Hansen Probing Arginine Side-Chains and Their Dynamics with Carbon-Detected NMR Spectroscopy: Application to the 42 kDa Human Histone Deacetylase 8 at High pH Angewandte Chemie International Edition 52

Article first published online: 10 FEB 2013 | DOI: 10.1002/anie.201209385

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Arginine side-chains play a distinct role because of their high pKa and perpetual positive charge. An NMR method is presented, based on carbon-detected 13Cζ15Nε correlation spectra, which allows probing the arginine side-chains and their dynamics at neutral-to-high pH. The methodology is demonstrated on human histone deacetylase 8.

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