Xiao-Guang Song, Prof. Shou-Fei Zhu, Xiu-Lan Xie and Prof. Qi-Lin Zhou Enantioselective Copper-Catalyzed Intramolecular Phenolic OH Bond Insertion: Synthesis of Chiral 2-Carboxy Dihydrobenzofurans, Dihydrobenzopyrans, and Tetrahydrobenzooxepines Angewandte Chemie International Edition 52
Efficient: A copper-catalyzed enantioselective intramolecular insertion of carbenoids into phenolic OH bonds has been developed. This method can be used for the synthesis of the title compounds in high yields and excellent enantioselectivities under mild and neutral conditions (see scheme). NaBArF=sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate.
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