Dr. Le Du, Prof. Dr. Peng Cao, Dr. Junwei Xing, Yazhou Lou, Liyin Jiang, Dr. Liangchun Li and Prof. Dr. Jian Liao Hydrogen-Bond-Promoted Palladium Catalysis: Allylic Alkylation of Indoles with Unsymmetrical 1,3-Disubstituted Allyl Acetates Using Chiral Bis(sulfoxide) Phosphine Ligands Angewandte Chemie International Edition 52
A DYKAT die hard: A new class of chiral BiSO-P ligands were effective for an unprecedented palladium-catalyzed asymmetric allylic alkylation of indoles with the racemic title acetates through a dynamic kinetic asymmetric transformation (DYKAT). The hydrogen bond formed between the sulfinyl group of the ligand and NH of indole plays an important role in the reaction.
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