Dr. Bill Morandi, Zachary K. Wickens and Prof. Dr. Robert H. Grubbs Practical and General Palladium-Catalyzed Synthesis of Ketones from Internal Olefins Angewandte Chemie International Edition 52
Make it simple! A convenient and general palladium-catalyzed oxidation of internal olefins to ketones is reported. The transformation occurs at room temperature and shows wide substrate scope. Applications to the oxidation of seed-oil derivatives and a bioactive natural product (see scheme) are described, as well as intriguing mechanistic features.
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