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Dr. Xiaofei Zeng, M. Sc. Qijian Ni, Prof. Dr. Gerhard Raabe and Prof. Dr. Dieter Enders A Branched Domino Reaction: Asymmetric Organocatalytic Two-Component Four-Step Synthesis of Polyfunctionalized Cyclohexene Derivatives Angewandte Chemie International Edition 52

Version of Record online: 25 JAN 2013 | DOI: 10.1002/anie.201209581

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Take two: By employing two equivalents of an aldehyde in an asymmetric organocatalytic domino reaction, the nucleophilic enamine intermediate is also converted into the corresponding iminium species through oxidation with o-iodoxybenzoic acid. Thus, polyfunctionalized cyclohexene derivatives are formed from two simple starting materials in good yields and stereoselectivities (see scheme; Bn=benzyl, EWG=electron-withdrawing group).

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