Sheng-Qi Xiang, Raghavendran L. Narayanan, Dr. Stefan Becker and Prof. Markus Zweckstetter N–H Spin–Spin Couplings: Probing Hydrogen Bonds in Proteins Angewandte Chemie International Edition 52
Sensitive information: Hydrogen bonds stabilize protein structures and are critical for many chemical and biological phenomena. NMR studies found that the one-bond 1H–15N scalar coupling constant is increased by up to 1.6 Hz when a hydrogen bond is formed. These coupling constants therefore provide a sensitive tool for studying protein structure.
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