Mag. Markus Ruetz, Dr. Carmen Gherasim, Prof. Dr. Karl Gruber, Dr. Sergey Fedosov, Prof. Dr. Ruma Banerjee and Prof. Dr. Bernhard Kräutler Access to Organometallic Arylcobaltcorrins through Radical Synthesis: 4-Ethylphenylcobalamin, a Potential “Antivitamin B12” Angewandte Chemie International Edition 52
Locked B12: 4-Ethylphenylcobalamin, a novel organometallic arylcobalamin, has been synthesized in a radical reaction. This vitamin B12 antimetabolite features a strong CoC bond, and represents a “locked” form of vitamin B12 (see picture). It may be used in animal studies to induce functional vitamin B12 deficiency artificially to help clarify still controversial issues related to the pathophysiology of vitamin B12 deficiency.
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