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Dr. Serena Mazzucchelli, Dr. Miriam Colombo, Paolo Verderio, Ewa Rozek, Francesco Andreata, Elisabetta Galbiati, Prof. Paolo Tortora, Prof. Fabio Corsi and Dr. Davide Prosperi Orientation-Controlled Conjugation of Haloalkane Dehalogenase Fused Homing Peptides to Multifunctional Nanoparticles for the Specific Recognition of Cancer Cells Angewandte Chemie International Edition 52

Version of Record online: 5 FEB 2013 | DOI: 10.1002/anie.201209662

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In control: The ligand positioning and orientation on multifunctional nanoparticles (MNP) are controlled by using a versatile bimodular approach that exploits an 11 amino acid (U11) homing peptide genetically fused with a haloalkane dehalogenase (HALO) enzyme. The resultant nanoparticles have good targeting efficiency and selectivity toward broadly occurring urokinase plasminogen activator receptor positive human cancer cells.

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