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Philipp Anstaett, Dr. Yuanhui Zheng, Thibaut Thai, Dr. Alison M. Funston, Prof. Dr. Udo Bach and Prof. Dr. Gilles Gasser Synthesis of Stable Peptide Nucleic Acid-Modified Gold Nanoparticles and their Assembly onto Gold Surfaces Angewandte Chemie International Edition 52

Version of Record online: 4 MAR 2013 | DOI: 10.1002/anie.201209684

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PNA does it better: Peptide nucleic acid (PNA) oligomers were attached to gold nanoparticles (AuNPs) through a variety of mono- and trithiol linkers. These functionalized particles had sufficient stability for sequence-specific self-assembly onto gold surfaces (see figure) in the absence of ions or surfactants. The nanoparticle surface densities obtained were superior to comparable DNA-modified AuNPs.

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