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Dr. Shikha Gandhi and Prof. Dr. Benjamin List Catalytic Asymmetric Three-Component Synthesis of Homoallylic Amines Angewandte Chemie International Edition 52

Version of Record online: 25 JAN 2013 | DOI: 10.1002/anie.201209776

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It takes three to make things go right: The first direct asymmetric three-component reaction of aldehydes, carbamates, and allyltrimethylsilane leading to enantioenriched homoallylic amines has been developed using a new chiral disulfonimide catalyst (see scheme). The method employs readily available, inexpensive, and nontoxic starting materials and is applicable to both aromatic and aliphatic aldehydes.

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