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Prof. Dr. Jin-Oh You, Dr. Peng Guo and Prof. Dr. Debra T. Auguste A Drug-Delivery Vehicle Combining the Targeting and Thermal Ablation of HER2+ Breast-Cancer Cells with Triggered Drug Release Angewandte Chemie International Edition 52

Version of Record online: 11 MAR 2013 | DOI: 10.1002/anie.201209804

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Covering all three bases: Drug-delivery vehicles that encapsulate doxorubicin (Dox) within a pH-sensitive matrix embedded with gold nanoparticles were synthesized with Herceptin–poly(ethylene glycol) conjugates on the surface for the specific binding of cancer cells (see picture; NIR=near infrared). Cell targeting was combined with enhanced cytotoxicity through triggered drug release (at pH 5–6) and thermal ablation (a photothermal effect).

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