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Prof. Dr. Lutz F. Tietze, Dipl.-Chem. Svenia-C. Duefert, Dr. Jérôme Clerc, Dr. Matthias Bischoff, Dipl.-Chem. Christian Maaß and Prof. Dr. Dietmar Stalke Total Synthesis of Linoxepin through a Palladium-Catalyzed Domino Reaction Angewandte Chemie International Edition 52

Article first published online: 12 FEB 2013 | DOI: 10.1002/anie.201209868

Thumbnail image of graphical abstract

Convergent and elegant: Linoxepin (see picture), a new lignan with an unusual oxepin moiety, has been synthesized in only 10 steps. The protecting-group-free total synthesis includes a palladium- catalyzed Sonogashira reaction and a domino carbopalladation/Heck reaction of an allylsilane.

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