Zeqian Li, Shaoxiong Zhang, Shoutao Wu, Xiaolei Shen, Liwei Zou, Fengqun Wang, Xiang Li, Fangzhi Peng, Prof. Hongbin Zhang and Prof. Zhihui Shao Enantioselective Palladium-Catalyzed Decarboxylative Allylation of Carbazolones: Total Synthesis of (−)-Aspidospermidine and (+)-Kopsihainanine A Angewandte Chemie International Edition 52
Version of Record online: 8 MAR 2013 | DOI: 10.1002/anie.201209878
Functionalized chiral carbazolones with α-quaternary carbon centers are formed through the ligand-controlled Pd-catalyzed enantioselective decarboxylative allylic alkylation of carbazolones (see scheme). This catalytic asymmetric reaction was employed as the key step in the total synthesis of aspidospermidine and (+)-kopsihainanine A.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf
Required = Required Field