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Zeqian Li, Shaoxiong Zhang, Shoutao Wu, Xiaolei Shen, Liwei Zou, Fengqun Wang, Xiang Li, Fangzhi Peng, Prof. Hongbin Zhang and Prof. Zhihui Shao Enantioselective Palladium-Catalyzed Decarboxylative Allylation of Carbazolones: Total Synthesis of (−)-Aspidospermidine and (+)-Kopsihainanine A Angewandte Chemie International Edition 52

Version of Record online: 8 MAR 2013 | DOI: 10.1002/anie.201209878

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Functionalized chiral carbazolones with α-quaternary carbon centers are formed through the ligand-controlled Pd-catalyzed enantioselective decarboxylative allylic alkylation of carbazolones (see scheme). This catalytic asymmetric reaction was employed as the key step in the total synthesis of aspidospermidine and (+)-kopsihainanine A.

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