Dr. Vijaya B. Kenche, Dr. Lin W. Hung, Keyla Perez, Irene Volitakes, Dr. Guiseppe Ciccotosto, Jeffrey Kwok, Nicole Critch, Nikki Sherratt, Mikhalina Cortes, Varsha Lal, Prof. Colin L. Masters, Kazuma Murakami, Prof. Roberto Cappai, Dr. Paul A. Adlard and Prof. Kevin J. Barnham Development of a Platinum Complex as an anti-Amyloid Agent for the Therapy of Alzheimer’s Disease Angewandte Chemie International Edition 52
Version of Record online: 10 FEB 2013 | DOI: 10.1002/anie.201209885
Brainwash! A platinum complex (see scheme) was developed that could be administered orally and reduce the amyloid burden in the brains of transgenic mouse models suffering from Alzheimer's disease. Analyses of brain tissues showed that treatment with the Pt compound led to a 26 % decrease in the number of amyloid β-peptide plaques.
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