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Markus Schober, Michael Toesch, Dr. Tanja Knaus, Dr. Gernot A. Strohmeier, Dr. Bert van Loo, Dr. Michael Fuchs, Prof. Florian Hollfelder, Prof. Peter Macheroux and Prof. Kurt Faber One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases Angewandte Chemie International Edition 52

Article first published online: 10 FEB 2013 | DOI: 10.1002/anie.201209946

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Hand in hand: The title transformation was achieved using a pair of sulfatases acting through inversion and retention of configuration on opposite substrate enantiomers. Using Pseudomonas aeruginosa arylsulfatase PAS with alkylsulfatase PISA1 in one-pot leads to sec-alcohols (80 to >99 % conversion) with 91 to greater than 99 % ee.

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