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Dr. Lichen Yin, Ziyuan Song, Dr. Qiuhao Qu, Kyung Hoon Kim, Nan Zheng, Catherine Yao, Isthier Chaudhury, Dr. Haoyu Tang, Dr. Nathan P. Gabrielson, Prof. Dr. Fatih M. Uckun and Prof. Dr. Jianjun Cheng Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-α siRNA against Systemic Inflammation Angewandte Chemie International Edition 52

Version of Record online: 22 APR 2013 | DOI: 10.1002/anie.201209991

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A functional package: Multifunctional supramolecular self-assembled nanoparticles (SSNPs) consist of a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA and induce potent TNF-α silencing in macrophages. Single gavage of SSNPs in mice depletes systemic TNF-α production at an siRNA dose as low as 50 μg kg−1, and thus protects mice from lipopolysaccharide-induced hepatic injury.

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