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Dr. Hongquan Zhang, Dr. Feng Li, Brittany Dever, Chuan Wang, Prof. Xing-Fang Li and Prof. X. Chris Le Assembling DNA through Affinity Binding to Achieve Ultrasensitive Protein Detection Angewandte Chemie International Edition 52

Version of Record online: 26 AUG 2013 | DOI: 10.1002/anie.201210022

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The concentration makes the difference: Binding of a target molecule to two affinity ligands brings the complementary oligonucleotides together, thereby dramatically increasing their local concentrations and enhancing the stability of the hybrids. The principle is used to generate binding-induced assembly of DNA probes containing various motifs and DNA-functionalized nanomaterials for ultrasensitive detection of specific proteins.

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