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Prof. Dr. Hiroki Shigehisa, Yoshihiro Suwa, Naho Furiya, Yuki Nakaya, Minoru Fukushima, Dr. Yusuke Ichihashi and Prof. Dr. Kou Hiroya Stereocontrolled Synthesis of Trichodermatide A Angewandte Chemie International Edition 52

Version of Record online: 18 FEB 2013 | DOI: 10.1002/anie.201210099

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Hard core made easy: The pentacyclic core of trichodermatide A was stereoselectively synthesized from a bis(1,3-cyclohexanedione) derivative by a ring-closing reaction followed by an intramolecular ketal formation (see scheme; PPTS=pyridinium p-toluenesulfonate). The first total synthesis of trichodermatide A was then completed by the introduction of three hydroxy groups.

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