Dipl.-Biol. Sebastian W. Fuchs, Dipl.-Bioinf. Kenan A. J. Bozhüyük, Dipl.-Bioinf. Darko Kresovic, Florian Grundmann, M. Sc. Veronica Dill, Dr. Alexander O. Brachmann, Dr. Nicholas R. Waterfield and Prof. Dr. Helge B. Bode Formation of 1,3-Cyclohexanediones and Resorcinols Catalyzed by a Widely Occuring Ketosynthase Angewandte Chemie International Edition 52
Overlooked, but widespread! A new class of ketosynthases (DarB) involved in the biosynthesis of 1,3-cyclohexanediones and dialkylresorcinols has been identified and characterized in detail. The presence of homologues in 89 different bacteria, including several pathogens, reveals that DarB as well as the corresponding natural products might be widespread, thus presenting a new but so far overlooked pathway to natural products.
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