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Dr. Per Haberkant, Dr. Reinout Raijmakers, Dr. Marjolein Wildwater, Timo Sachsenheimer, Priv.-Doz. Dr. Britta Brügger, Dr. Kenji Maeda, Dr. Martin Houweling, Dr. Anne-Claude Gavin, Priv.-Doz. Dr. Carsten Schultz, Prof. Gerrit van Meer, Prof. Albert J. R. Heck and Prof. Joost C. M. Holthuis In Vivo Profiling and Visualization of Cellular Protein–Lipid Interactions Using Bifunctional Fatty Acids Angewandte Chemie International Edition 52

Version of Record online: 28 FEB 2013 | DOI: 10.1002/anie.201210178

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Bifunctional lipid technology: Cells convert externally added photoactivatable and “clickable” fatty acids into a variety of bifunctional phospholipids that can be covalently linked to their protein-binding partners by irradiation with UV light. Derivatization of the clickable group with a reporter molecule makes it possible to identify and image the lipid-bound proteins in situ (see scheme).

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