Hao Xu, Jian-Ping Qu, Dr. Saihu Liao, Hu Xiong and Prof. Dr. Yong Tang Highly Enantioselective [3+2] Annulation of Cyclic Enol Silyl Ethers with Donor–Acceptor Cyclopropanes: Accessing 3a-Hydroxy [n.3.0]Carbobicycles Angewandte Chemie International Edition 52
A new fuse: The title reaction was realized using a new bisoxazoline (BOX)/CuII catalyst. This reaction works well with cyclic enol silyl ethers of different sizes, and can be extended to dienol and benzene-fused substrates, thus providing an effective and general access to a range of 3a-hydroxy [n.3.0]carbobicycles which are found as a core structure in many natural products. TBDPS=tert-butyldiphenylsilyl.
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